Current Issue : October-December Volume : 2023 Issue Number : 4 Articles : 2 Articles
The present investigation aimed to develop and evaluate thermoreversible in-situ nasal gel containing curcumin nanoparticles. Curcumin nanoparticles were prepared by the ionic gelation method. These formulations were evaluated for entrapment efficiency, particle size, zeta potential and in-vitro drug release. Particle size and entrapment efficiency of the F1 formulation were found to be 299 nm and 83.1% respectively. Since the formulation, F1 showed a maximum amount of drug released in a controlled manner for a prolonged time. Hence F1 formulations were selected as optimized and further used for thermoreversible in-situ nasal gel by using 22 factorial designs. The thermoreversible nasal gel was evaluated for the gelation temperature (33°C) viscosity (10550cps) and spreadability (17.29±0.3 gm*cm/sec). Further, the prepared gel (FG3) was evaluated for an ex-vivo permeation study for 12 hours and it showed a maximum amount of drug release in a controlled manner. The % CDR of thermoreversible in-situ gel formulation FG3 was found to be 86.27% which follows the Higuchi model. The 'n' value of the formulation was found to be more than 0.5. This indicates that the release approximates the non-fickian diffusion mechanism....
Personalized medicine is an evolving healthcare paradigm that tailors medical treatment to the individual characteristics of each patient. It encompasses a range of approaches, including genomics, proteomics, pharmacogenomics and clinical data analysis, to optimize therapeutic strategies. This review article provides an in-depth analysis of personalized medicine, highlighting its historical development, current applications, challenges and future prospects. We discussed key technologies, ethical considerations and the potential impact of personalized medicine on healthcare systems and patient outcomes....
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